Everything about Indoleamine 2 3-dioxygenase totally explained
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| Name = Indoleamine-pyrrole 2,3 dioxygenase
| HGNCid = 6059
| Symbol = INDO
| AltSymbols =; CD107B; IDO
| OMIM = 147435
| ECnumber = 1.13.11.42
| Homologene = 48082
| MGIid = 96416
| GeneAtlas_image1 = PBB_GE_INDO_210029_at_tn.png
| Function =
| Component =
| Process =
| Orthologs =
}}
Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.42) is an
immunomodulatory enzyme secreted by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors).
IDO is the first and rate limiting enzyme of
Tryptophan catabolism through
Kynurenine pathway, thus causing depletion of tryptophan which can cause halted growth of microbes as well as T cells.
It catalyzes conversion of
L-tryptophan to
N-formylkynurenine.
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